Chikungunya aftereffects and Chikungunya Arthritis

After recovery from Chikungunya fever persistent pain in Joints is due to Chikungunya Arthritis an aftereffect of chikungunya. Chikungunya Arthritis is also known as Post Viral Arthropathy. The bite from aedes aegypti mosquito has debilitating outcomes and the patient can get confined to bed for several weeks.

The most common aftereffects of Chikungunya include:

  • Pain in Joints which can persist for weeks
  • Feeling of weakness.
  • Lethargy and Fatigue.

The pain in the Joints is due to the counterattack of the immune system to the viral infection. The body recognizes some of its own cells as infective agents and hence attacks   some body cells along with the Chikungunya Virus. Antibodies activated by a viral attack often end up striking cartilages at the joints. This leads to swelling in the joints, often restricting movement. More than 50% of patients reported long term joint pain.  Some patients with joint pain do not respond well to the analgesics (painkillers) indicating damage of the nervous system.

People having a healthy lifestyle, healthy dietary habits usually recover faster than compared to others. The pain can handicap the person in a way where they cannot perform their daily routine chores comfortably.

Management of Joint pain:

The pain can be managed by mild exercises, cold packs, and pain killers. Ayurvedic medicine may also provide relief from the debilitating pain of the joints. Physiotherapy and mild exercise is also useful for management of pain and recovery. Simple exercise can help strengthen the muscles around the joints and can reduce pain and stiffness. Some of the useful simple movement exercises are:

  • Sit on a chair and then extend each leg parallel to the floor and hold it for a few seconds before lowering it. Repeat this less than 10 times at a time. You can do this 2 or 3 times a day.
  • Walk for 10 to 20 minutes at a mild pace. Avoid sitting for long periods of time at a stretch.
  • Do simple movement exercises by moving fingers, hand and elbow.
  • Some patients may need long term lifestyle changes for pain management.

 

New Gene Discovery can yield new treatment for Type 2 Diabetes

New research has found that blocking the gene – called TNFR5 – halted the destruction process of insulin producing cells, a discovery that could lead to new treatments for type 2 diabetes.

Insulin regulates the blood sugar level. Insulin helps store the sugar in your liver and releases sugar when the sugar level is low.

Using high-density microarray analysis, more than 31,000 genes associated with the pancreas were evaluated, which would determine which ones were most sensitive to glucose and fatty acids.

The researchers found that the gene TNFR5 had the highest sensitivity to glucose and fatty acids, and  an overexpression of this gene led to beta cell destruction. This led to the finding inhibiting TNFR 5 activity could be a promising treatment for type 2 diabetes.

 

MRDC’s New Venture: Promote your Buisness Digitally

Medical Research and Development Consortium reaches to the worldwide audience with the latest industry news, information, products from the Medical/pharma domain.

Our Key Activities include:

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To reach to targeted audience our sponsored content provides an opportunity to communicate with people interested in the specializing field. We would be helping you to reach out to wide audience by sending mass email campaign for the promotion and marketing of any sponsored content. Our key audience /readership members are researchers, academia, and industry professionals.

We have been a trusted partner with various institutions in publication of scientific content and now we are entering a new arena where we would be joining the scientific community in a broader way and with some of the best names in the industry.

Zika Virus : Harmful for Pregnant Women

Zika virus is spreading rapidly with around 3–4 million victims already registered by World Health Organisation. Indian Medical Association has issued a strict warning to pregnant women, advising them to avoid visiting tropical and sub-tropical nations, mostly falling in the regions of Africa and Latin America. Zika virus mostly affects Newborn babies causing extremely high fever, microcephaly; damage to newborn babies brain causing smaller head size for entire life. The ailment is uncurable. Cases are reported mainly in Columbia, Venezuela, Brazil, Mexico, Caribbean islands, Niger, Egypt, Gabon, Sierra Leone, Tanzania, and Uganda. There is a threat that the virus may spread to Asian nations including India, Indonesia, Malaysia, the Philippines, Thailand, and Vietnam.

Based on the rising cases of dengue in India, it also offers the most fertile condition for breeding of Zika virus. The tropical climate can also help the virus to multiply. According to Indian Council for Medical Research in New Delhi, efforts have to be initiated to prevent the nation from the deadly disease outbreak.

New Discovery in Anemia Treatment

A new way to trigger the red blood cell production reveals a surprising role of dendritic cells involved in red blood cell production.

The team that did the work, led by Thomas J. Braciale, a professor of pathology and microbiology at the University of Virginia School of Medicine in Charlottesville, describes the discovery in The Journal of Clinical Investigation.

Anemia is a condition that develops when your blood lacks enough healthy red blood cells or hemoglobin. Hemoglobin is a main part of red blood cells and binds oxygen. If you have too few or abnormal red blood cells, or your hemoglobin is abnormal or low, the cells in your body will not get enough oxygen. Symptoms of anemia — like fatigue — occur because organs aren’t getting what they need to function properly.

 The researchers, who were running a test of the flu virus in mice, discovered an unexpected effect that led them to discover dendritic cells also have a completely different, and previously unknown, role.

They saw the effect when they injected the mice with the flu virus and an antibody that blocked a certain molecule expressed by dendritic cells.

The first thing that happened was the mice’s spleen become huge. This totally unexpected result baffled the researchers, so they ran the test again, and the same thing happened. Prof. Braciale takes up the story:

“We did it again and I didn’t believe it, and we did it again and I didn’t believe it. I asked whether you needed to flu infect the mice when you injected this antibody. So the postdoc [a lab member] did the experiment, and he just injected the antibody without flu injecting the mice. Giant spleens. After much consultation, after talking with my colleagues in Pathology, we decided we were inducing stress erythropoiesis.”

Prof. Braciale says it appears that the process of regulating stress in the body involves dendritic cells. Stress can arise from a number of sources – it can be infection, inflammation; it can be anemia, it can be hemorrhage.

Although there is a lot of work to do before a treatment that triggers dendritic cells to make red blood cells is ready for use in humans, Prof. Braciale is optimistic, because, as he explains:

“We know that the same things can be done in humans in the following sense. There are mice called humanized mice. These are mice that are engineered so they have a human blood system. And if you inject these mice with this antibody, they’ll make red blood cells.”

Courtesy : MNT

Fat molecules boosts the effectiveness of flu vaccine

Flu is a common infectious viral illness spread by coughs and sneezes. Influenza spreads around the world in a yearly outbreak, resulting in about three to five million cases of severe illness and about 250,000 to 500,000 deaths.

The best protection against flu is the seasonal flu vaccine, which is developed every year based on a prediction of which viruses are likely to be circulating. However, such predictions are sometimes far from accurate; earlier this year, a report from the Centers for Disease Control and Prevention (CDC) revealed that the 2014-15 flu vaccine was only 23% effective across all age groups.

For their study, published in the journal mBio, the researchers gave a group of mice a low dose of an inactivated influenza A vaccine in which the synthetic lipopeptide had been added, while another group was given an inactivated influenza A vaccine without the adjuvant. Three days later, the mice were exposed to the flu strain that was included in the vaccine, as well as an “unmatched” strain that was not.

 Courtesy: Medical News today

Test to detect Alzheimer’s disease before onset of Symptoms

Robert Nagele, PhD, at the American Osteopathic Association’s Osteopathic Medical Conference and Exposition (OMED15) in Orlando, FL.explains how autoantibodies act as blood-based biomarkers in order to detect numerous diseases and identify the stage to which a disease has progressed.

An individual’s autoantibody profile depends on various factors like   age, gender and the presence of specific diseases or injuries. Diseases cause changes in autoantibody profiles that, when detected, can serve as biomarkers and help in identifying the disease.

Dr Nagele says:

“There are significant benefits to early disease detection because we now know that many of the same conditions that lead to vascular disease are also significant risk factors for Alzheimer’s. People found to have preclinical disease can take steps to improve their vascular health, including watching their diet, exercising and managing any weight and blood pressure issues to help stave off or slow disease progression.”

 

Courtesy : Medical News Today

New Test “Virocap” can detect all Infecting Viruses

New Test “Virocap” can detect all Infecting Viruses

Researchers have developed a new test, ViroCap, This can detect almost any virus infecting humans and animals . For the benefit of patient and research the technology will be publicly available worldwide.

According to research at Washington University School of Medicine in St. Louis, where the technology was developed. With this test, you don’t have to know what you’re looking for,” says the study’s senior author, Gregory Storch, MD. “It casts a broad net and can efficiently detect viruses that are present at very low levels. We think the test will be especially useful in situations where a diagnosis remains elusive after standard testing or in situations in which the cause of a disease outbreak is unknown.”

The test is known as virocap and examines about 2 million sequences of genetic data from viuses in human and animals. ViroCap is 52% more accurate than polymerase chain reaction (PCR) tests, which are currently used for diagnoses.

“It also may be possible to modify the test so that it could be used to detect pathogens other than viruses, including bacteria, fungi and other microbes, as well as genes that would indicate the pathogen is resistant to treatment with antibiotics or other drugs,” said co-author Kristine Wylie, PhD.

In two clinical trials involving a total of 22 subjects, the test, called ViroCap, detected 32 viruses; standard testing through genome sequencing on the same groups revealed only 21. Storch says the test could be easily modified to include additional genetic sequences when new viruses are discovered—and eventually, study co-author Kristine Wylie says, it could could be expanded to detect other kinds of pathogens, such as bacteria, fungi, and other assorted microbes. 

Courtesy : Genome Research

 

Nuclear Research and Surgery

A JRC invention initially stemming from its research in the nuclear sector will soon be used by hospitals for minimally-invasive robotic surgery. TELELAP Advanced Laparoscopy through Force refleCTion,” is an advanced multi-port robotic system that will empower surgeons with new technologies such as eye-tracking and haptics, allowing them eye-control of the camera and touch sensation during surgery. Hospitals will be able use the most advanced technology while running at low operational costs, as the system can use current surgical instruments.

Source :  European Commission, Joint Research Centre (JRC), European Commission, Joint Research Centre (JRC). “From nuclear research to surgery technology.” ScienceDaily.

World Heart Day: 29th September 2015

World Heart Day: 29th September 2015

World Heart Day is an annual event which takes place on 29 September every year. The World Heart Federation is dedicated to leading the global fight against cardiovascular disease (CVD) – including heart disease and stroke. Each year’s celebrations have a different theme, reflecting key issues and topics relating to heart health. This year World Heart Day is dedicated to exposing how much our environments can impact on and increase CVD risk factors. CVD can be prevented by addressing risk factors, such as tobacco use, unhealthy diet and physical inactivity. 

“World Heart Day encourages us to reduce our cardiovascular risk, and to promote a heart-healthy planet for all those around us.”

Courtesy: World Health Federation.

5 Best foods for a Healthy Heart

Salmon : Salmon is considered as superstar of Heart Healthy foods. Salmon is considered to be healthy due to its high protein, high omega-3 fatty acids, and high vitamin D content. It reduces the risk of arrythima (irregular heart Beat), atherosclerosis . Intake of salmon twice a week ois recommended for a healthy heart.

Oatmeal: It is high in soluble fiber which lowers the cholesterol. It eliminates the cholesterol from the body.  Because of its high content of complex carbohydrates and water-soluble fiber that encourages slow digestion and stabilizes blood-glucose levels , its consumption is highly recommended.

Blueberries: It has been shown to improve blood fat balances, including reduction in total cholesterol, raising of HDL cholesterol, and lowering of triglycerides. At the same time, blueberry intake has been shown to help protect the blood components (like LDL cholesterol) from oxygen damage that could lead to eventual clogging of the blood vessels.

Dark Chocolate: Eating a small amount of dark chocolate two or three times each week can help lower your blood pressure. Dark chocolate improves blood flow and may help prevent the formation of Blood clots. Dark chocolate also helps reduce the risk of stroke.

Nuts: These include walnuts,almonds, pitachios, Peanuts . Nuts contains lot of fibres which are good for the heart. They also contain Vitamin E which aids in lowering of bad cholesterol. Pistachios contain potassium and fibres. Almond’s skin is full of heart-protecting compounds called flavonoids.Walnuts help to lower the bad form of cholesterol (LDL).

 

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