In the drug development phase animal testing plays an important role to detect any toxic effects of the drug.
- Human primary renal proximal tubular cells or similar cells derived from human embryonic stem cells (hESCs) were used earlier.
- The team used human iPSCs, which can can be generated from cells that are easily found in the body ex : skin.
Scientists from the Institute of Bioengineering and Nanotechnology (IBN) in Singapore describe how they developed the platform using human induced pluripotent stem cells (iPSCs) and machine learning methods.As well as predicting toxicity, they note that the new platform also correctly identifies the injury mechanisms that a drug may induce, which can improve understanding of the compound and its effects.
The tool will be useful to both Pharmaceutical sector as well as the food and cosmetics industry.
Senior author Dr. Daniele Zink, IBN team leader and principal research scientist, says:”We have developed the fastest and most efficient protocol for generating kidney cells from induced pluripotent stem cells. Within 8 days, it yielded highly pure kidney cells that were suitable for compound screening.”
Source : MNT