₹250 crore facility setup by Indian immunologicals Ltd at Hyderabad

The Indian Immunologicals Limited (IIL) is a leading biologicals company in the country. It has set up a new facility with an investment of Rs. 250 crore near Hyderabad and is set to become India’s largest producer of animal health formulations.

Spread over 47 acres at Karkapatla is IIL’s second manufacturing unit in Hyderabad and will significantly expand the company’s manufacturing capabilities. The IIL has developed this facility considering the growing demand for the next 10 years for human vaccines and animal health formulations.

The first phase of human vaccine facility at IIL has the capacity to produce eight million doses of human rabies vaccine, while the animal health formulation facility is equipped to produce an estimated capacity of 300 million tablets, 100 million bolus, and 20 million vials of injectables.

Deputy managing director K. Anand Kumar said, “The facility will strengthen IIL’s position in the industry and will immensely increase our manufacturing capabilities. We are expecting this plant to play a key role in manufacturing top quality vaccines with the most recent German technology.”

Source: IANS

Fat molecules boosts the effectiveness of flu vaccine

Flu is a common infectious viral illness spread by coughs and sneezes. Influenza spreads around the world in a yearly outbreak, resulting in about three to five million cases of severe illness and about 250,000 to 500,000 deaths.

The best protection against flu is the seasonal flu vaccine, which is developed every year based on a prediction of which viruses are likely to be circulating. However, such predictions are sometimes far from accurate; earlier this year, a report from the Centers for Disease Control and Prevention (CDC) revealed that the 2014-15 flu vaccine was only 23% effective across all age groups.

For their study, published in the journal mBio, the researchers gave a group of mice a low dose of an inactivated influenza A vaccine in which the synthetic lipopeptide had been added, while another group was given an inactivated influenza A vaccine without the adjuvant. Three days later, the mice were exposed to the flu strain that was included in the vaccine, as well as an “unmatched” strain that was not.

 Courtesy: Medical News today

Drug Screening Tool reduces need for Animal Testing

In the drug development phase animal testing plays an important role to detect any toxic effects of the drug.

  • Human primary renal proximal tubular cells or similar cells derived from human embryonic stem cells (hESCs) were used earlier.
  • The team used human iPSCs, which can can be generated from cells that are easily found in the body ex : skin.

Scientists from the Institute of Bioengineering and Nanotechnology (IBN) in Singapore describe how they developed the platform using human induced pluripotent stem cells (iPSCs) and machine learning methods.As well as predicting toxicity, they note that the new platform also correctly identifies the injury mechanisms that a drug may induce, which can improve understanding of the compound and its effects.

The tool will be useful to both Pharmaceutical sector as well as the food and cosmetics industry.

Senior author Dr. Daniele Zink, IBN team leader and principal research scientist, says:”We have developed the fastest and most efficient protocol for generating kidney cells from induced pluripotent stem cells. Within 8 days, it yielded highly pure kidney cells that were suitable for compound screening.”


Source : MNT

Test to detect Alzheimer’s disease before onset of Symptoms

Robert Nagele, PhD, at the American Osteopathic Association’s Osteopathic Medical Conference and Exposition (OMED15) in Orlando, FL.explains how autoantibodies act as blood-based biomarkers in order to detect numerous diseases and identify the stage to which a disease has progressed.

An individual’s autoantibody profile depends on various factors like   age, gender and the presence of specific diseases or injuries. Diseases cause changes in autoantibody profiles that, when detected, can serve as biomarkers and help in identifying the disease.

Dr Nagele says:

“There are significant benefits to early disease detection because we now know that many of the same conditions that lead to vascular disease are also significant risk factors for Alzheimer’s. People found to have preclinical disease can take steps to improve their vascular health, including watching their diet, exercising and managing any weight and blood pressure issues to help stave off or slow disease progression.”


Courtesy : Medical News Today

New Test “Virocap” can detect all Infecting Viruses

New Test “Virocap” can detect all Infecting Viruses

Researchers have developed a new test, ViroCap, This can detect almost any virus infecting humans and animals . For the benefit of patient and research the technology will be publicly available worldwide.

According to research at Washington University School of Medicine in St. Louis, where the technology was developed. With this test, you don’t have to know what you’re looking for,” says the study’s senior author, Gregory Storch, MD. “It casts a broad net and can efficiently detect viruses that are present at very low levels. We think the test will be especially useful in situations where a diagnosis remains elusive after standard testing or in situations in which the cause of a disease outbreak is unknown.”

The test is known as virocap and examines about 2 million sequences of genetic data from viuses in human and animals. ViroCap is 52% more accurate than polymerase chain reaction (PCR) tests, which are currently used for diagnoses.

“It also may be possible to modify the test so that it could be used to detect pathogens other than viruses, including bacteria, fungi and other microbes, as well as genes that would indicate the pathogen is resistant to treatment with antibiotics or other drugs,” said co-author Kristine Wylie, PhD.

In two clinical trials involving a total of 22 subjects, the test, called ViroCap, detected 32 viruses; standard testing through genome sequencing on the same groups revealed only 21. Storch says the test could be easily modified to include additional genetic sequences when new viruses are discovered—and eventually, study co-author Kristine Wylie says, it could could be expanded to detect other kinds of pathogens, such as bacteria, fungi, and other assorted microbes. 

Courtesy : Genome Research


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Noble Prize 2015 won by trio Scientists for Parasite fighting Drugs

The 2015 Nobel Prize is awarded  in Physiology or Medicine with one half jointly to William C. Campbell and Satoshi Ōmura for their discoveries concerning a novel therapy against infections caused by roundworm parasites and the other half to Youyou Tu for her discoveries concerning a novel therapy against Malaria.

William C. Campbell and Satoshi Ōmura discovered a new drug, Avermectin, the derivatives of which have radically lowered the incidence of River Blindness and Lymphatic Filariasis, as well as showing efficacy against an expanding number of other parasitic diseases. Youyou Tu discovered Artemisinin, a drug that has significantly reduced the mortality rates for patients suffering from Malaria.

These two discoveries have provided humankind with powerful new means to combat these debilitating diseases that affect hundreds of millions of people annually. The consequences in terms of improved human health and reduced suffering are immeasurable.

Source: MLA style: “The 2015 Nobel Prize in Physiology or Medicine – Press Release”. Nobelprize.org. Nobel Media AB 2014. Web. 6 Oct 2015.

Nuclear Research and Surgery

A JRC invention initially stemming from its research in the nuclear sector will soon be used by hospitals for minimally-invasive robotic surgery. TELELAP Advanced Laparoscopy through Force refleCTion,” is an advanced multi-port robotic system that will empower surgeons with new technologies such as eye-tracking and haptics, allowing them eye-control of the camera and touch sensation during surgery. Hospitals will be able use the most advanced technology while running at low operational costs, as the system can use current surgical instruments.

Source :  European Commission, Joint Research Centre (JRC), European Commission, Joint Research Centre (JRC). “From nuclear research to surgery technology.” ScienceDaily.

Cardiological Society of India launches book on developing healthy heart lifestyle

The Cardiological society of Bengal was started on the 11th April, 1946  with Dr. B.C. Roy, the legendary physician as its first President. Cardiological Society of India has twenty five branches of its own spread all over the country.

The Cardiological Society of India is an active member of the International Society & federation of Cardiology and Asian Pacific Society of Cardiology and also SAARC society of Cardiology and jointly working with European Society of Cardiology (ESC) and American College of Cardiology (ACC). 

The present membership strength of the Society including overseas members has reached more than four thousand. Every year the World Heart Day is observed at CSI HQ and all other branches of CSI on 29th September

“Ten Commandments for Creating Heart-Healthy Homes”, the book is available in English and 10 other Indian languages and would be circulated among school children across the country.

CSI general secretary Dr Mrinal Kanti Das said: “Prevention is the best way to fight cardiovascular diseases and so we have chosen school children as the target audience.

“The book also seeks to address the issue of obesity and hypertension to which our younger population is increasingly falling prey to,” said Dr Das.

“The book can play a big part in preventing cardiovascular diseases and we will talk with the other departments concerned to ensure if the contents can be displayed at all medical facilities whether government or private so that awareness can be widely spread,” said Dr Bachani.

NMIMS Management Aptitude Test (NMAT) 2016

Last date of application : Tuesday, October 06, 2015

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